ABSTRACT
Naringin is a flavonoid isolated from different citrus fruits like Grapefruit, Orange, Pomelo, Lemon, etc, which are commonly called local fruit. Naringin is found in the white spongy portion of citrus peel. Its content varies from 0.65 mg/gm in the mandarin peel to 14.40mg/gm in the grapefruit peel. Naringin is metabolized to the flavanone naringenin by the enzyme Naringinase present in the liver. It can be analyzed by using various analytical techniques such as HPLC, TLC, UV, HPTLC, mass spectroscopy, Liquid chromatography, chiral chromatography and LC/Mass spectroscopy. Naringin can act as an antioxidant and scavenge free radicals. Naringin mainly focuses on in-vitro and in-vivo animal studies showing its beneficial effects on cardioprotective, antioxidant, anti-inflammatory, antimicrobial, hypolipemiant, neurological, thermogenic, pulmonary disorders and antidiabetic. Naringin is also treated as a most promising treatment strategy against Covid-19 due to its antiviral and anti-inflammatory effects. Recently, Naringin has proven its activity in various molecular docking studies. Naringin keeps the body healthy against various illnesses and major lifestyle disorders.Copyright All © 2023 are reserved by International Journal of Pharmaceutical Sciences and Research.
ABSTRACT
Introduction: COVID-19 has caused concern in the Peruvian population due to the health impact it generates and given the slow progress of vaccination, people opt for pharmacological and non-pharmacological measures to prevent the disease. Objective: Analyze the association of pharmacological and non-pharmacological preventive measures during the COVID-19 pandemic with the characteristics of the inhabitants of Virú, Peru. Methods: A cross-sectional, correlational design was applied. A questionnaire of questions was used based on the characteristics of the inhabitants (age, sex and type of work) and food consumption, use of solutions and medicines for the prevention of COVID-19. The presence of COVID-19 was evaluated with the rapid test called Standard™ COVID 19 IgM/IgG;the sample was of 191 residents who went to Guadalupito Health Center in Virú. Results: The non-pharmacological measures most frequently applied by villagers during the COVID-19 pandemic were the consumption of citrus fruits (79%), garlic, onions (42%) and kion (26%). The pharmacological ones were ivermectin (14%) and paracetamol (12%). None of the measures were associated with the presence of COVID-19. Conclusions: Health professionals should emphasize through the different media that the measures analyzed in this study cannot prevent COVID-19. This constitutes valuable information for those people who do not take into account the usefulness of vaccines and challenge the disease by limiting their lives, with the exclusive use of certain foods, herbs and medicines.
ABSTRACT
The purpose of this research is to provide evidence-based natural therapies and foods that will enhance the immune system to fight the virus SARS CoV-2 and cancer. Minority populations that include Black African Americans and Hispanics are experiencing higher mortality rates due to both socioeconomic and lifestyle factors in the US and globally. Successful lessons learned from controlling previous 1918 pandemic flu will be discussed. Hypotheses: We hypothesize that targeting lifestyle factors such as diet, exercise, and hydrothermal therapy that enhance the immune system can effectively control and reduce the risk to COVID-19 disease and cancer simultaneously. The target cells for the SARS CoV-2 virus contain the ACE2 and TMPRSS2 receptors which serve as portals of entry. They are expressed throughout the body including the nose, lungs, heart, bladder, pancreas, kidneys and brain found on the epithelial and vascular tissue cells of these organs. Covid-19 affects multiple organs in the body and disrupts the innate immune system, especially the natural killer cells, monocytes, and neutrophils. Studies have shown that countries where BCG was used have less than 10% of COVID-19 cases and countries that do not use the BCG vaccine such as the US and Italy had high cases. It was also seen that people who had higher natural killer cell activity had 100% survival rates. Enhancing the innate immune system through natural therapies has shown to enhance immune cells to fight COVID-19 as well as cancer and destroy it. Methodology: Our research is exploratory and is based on recently published literature on COVID-19 diseases. The following databases were searched: CINAHL, Web of Science, PubMed, EBSCOHost, Google Scholar, Academic Search Complete, AccessMedicine, MedlinePlus, Nutrition Care Manuel, JSTOR and Publons. Results: During the Spanish flu pandemic death rates of those who received the best medical care was 6.7% compared with those who received hydrotherapy at 1.34%. Hydrotherapy will increase the body temperature and stimulate the activity of the immune cells, which can kill the viruses. Increasing the body temperature to 39.5 degrees centigrade was shown to kill the virus. Following the hot water bath with cold treatment was shown to be even more effective. Many foods have been found to enhance the immune system and to fight the flu virus. Foods such as blueberries, garlic, and probiotics were shown to improve natural killer activity. Vitamin C, Vitamin D, Zinc, and selenium play a role in immunity. Foods rich in antioxidants such as kale, blueberries, red bell peppers, and all citrus fruits also help enhance the immune system. During the 1918 flu pandemic that received hydrotherapy and other natural remedies, out of the 120 students and staff exposed, there were 90 patients, none very sick, and there were no deaths. Natural remedies used in the Spanish flu pandemic and should be instituted to help enhance immunity and lessen the deadly impact of COVID-19 cancer patients.
ABSTRACT
COVID-19 pandemic has infected more than 208 million people and accounted for more than 4.5 million deaths worldwide. In our present study, Najran university (NU) students’ knowledge, attitude and practice (KAP) towards COVID-19 was assessed using twenty, ten and eight-item scale questions respec-tively. Similarly, use of herbal and nutritional supplements to protect and cure against COVID-19 infections was measured including type, source of information and factors enforcing the use of such supplements. Addi-tionally, students shared their beliefs about immune enhancing potential of various nutritional components. SPSS package was used to perform statistical analyses. A total of 94 (67%) responses were obtained from male undergraduate pharmacy students. The students with good knowledge, positive attitude and proper practice towards COVID-19 were 29.6%, 85.2%, and 72.8%. respectively. Almost half of students used some herbal and nutritional supplements as protective measure against the COVID-19 infection. As forecasted, honey (34.6%), ginger (33.3%), and vitamin C (32.1%) were the most commonly used supplements. More than half students believe that using garlic (60.5%), black seeds (53.5%), citrus fruits (53.1%), and ginger tea (50.6%) will boost the immunity. Considering the fact that in-campus teaching has resumed in Saudi Arabian universities, amalgamate with peers would be common, hence adequate level of KAP towards COVID-19 is essential. Perhaps, getting COVID-19 vaccine shots are mandatory to attend in-campus classes in Saudi Arabia, still following precautionary measure are obligatory.